Corpus ID: 56029811

Invasin of Yersinia pseudotuberculosis is not a polyclonal activator of mouse B lymphocytes

@article{Medeiros2006InvasinOY,
  title={Invasin of Yersinia pseudotuberculosis is not a polyclonal activator of mouse B lymphocytes},
  author={B. M. Medeiros and Eloisa Elena Cangiani and L. Higuti and L. C. Satomi and C. D. Souza and A. C. Silva and J. M. Maia and D. Falc{\~a}o},
  journal={Revista de Ci{\^e}ncias Farmac{\^e}uticas B{\'a}sica e Aplicada},
  year={2006},
  volume={27},
  pages={221-227}
}
Department of Biological Sciences School of Pharmaceutical Sciences Sao Paulo State University, UNESP, Araraquara, SP 
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Production of Autoantibodies Associated with Polyclonal Activation in Yersinia enterocolitica O:8‐Infected Mice
TLDR
It was concluded that infection of mice with either the virulent strain of Y. enterocolitica O:8 or with its plasmidless isogenic pair resulted in the polyclonal activation of the splenic B lymphocytes including some autoreactive clones. Expand
Suppression of T and B Lymphocyte Activation by a Yersinia pseudotuberculosis Virulence Factor, Yoph
TLDR
It is demonstrated that after a transient exposure to Y. pseudotuberculosis, T and B cells are impaired in their ability to be activated through their antigen receptors, and a mechanism by which the pathogenic bacteria may modulate a wide range of T andB cell–mediated immune responses is suggested. Expand
Increased virulence of Yersinia pseudotuberculosis by two independent mutations
TLDR
It is shown that mutation of the invasin gene in Y. pseudotuberculosis abolishes the ability of the bacteria to invade HeLa cells, which may provide insight into the rise and fall of plague epidemics caused by Y. pestis. Expand
Effects of Yersinia enterocolitica O:3 Derivatives on B Lymphocyte Activation In Vivo
TLDR
Results suggest that SPF Swiss mice inoculated with any one of the Y. enterocolitica O:3 derivatives tested exhibited polyclonal activation of B lymphocytes as a result of stimulation by various bacterial components and not only LPS stimulation. Expand
Coordinate involvement of invasin and Yop proteins in a Yersinia pseudotuberculosis-specific class I-restricted cytotoxic T cell-mediated response.
TLDR
It is demonstrated that Lewis rats infected with virulent strains of Y. pseudotuberculosis, mount a Yersinia-specific, RT1-A-restricted, CD8+ T cell-mediated, cytotoxic response. Expand
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TLDR
Analysis of the course of infection revealed that the inv mutant had distinct differences relative to wild type in the distribution of visible infectious foci and in tissue colonization; however, the mutant and wild-type strains had similar LD50 values for both orally and intraperitoneally infected mice. Expand
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TLDR
Analysis of the course of infection showed that the mutant Y. enterocolitica inv mutant had distinct differences relative to wild type in the distribution of visible infectious foci and in tissue colonization; however, the mutant and wild-type strains had similar median lethal doses for both orally and intraperitoneally infected mice. Expand
Pathogenesis of defined invasion mutants of Yersinia enterocolitica in a BALB/c mouse model of infection
TLDR
It is found that YadA is necessary for persistence of Y. enterocolitica in Peyer's patches, and consistent with this observation, the yadA mutant was avirulent for mice infected either orally or intraperitoneally. Expand
Invasin of Yersinia pseudotuberculosis activates human peripheral B cells
TLDR
The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29) and an isogenic invA mutant failed to activate B cells. Expand
Reevaluation of the virulence phenotype of the inv yadA double mutants of Yersinia pseudotuberculosis
TLDR
New constructs of the inv yadA mutants of Y. pseudotuberculosis were made and tested in mice and maintained the same virulence as the wild-type strain, which may in part account for the difference in the results. Expand
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