Invariants reveal multiple forms of robustness in bifunctional enzyme systems.

@article{Dexter2015InvariantsRM,
  title={Invariants reveal multiple forms of robustness in bifunctional enzyme systems.},
  author={Joseph P. Dexter and Tathagata Dasgupta and Jeremy Gunawardena},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2015},
  volume={7 8},
  pages={883-94}
}
Experimental and theoretical studies have suggested that bifunctional enzymes catalyzing opposing modification and demodification reactions can confer steady-state concentration robustness to their substrates. However, the types of robustness and the biochemical basis for them have remained elusive. Here we report a systematic study of the most general… CONTINUE READING