Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency.

  title={Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency.},
  author={David A. Fulcher and Danielle T Avery and Nicole L. Fewings and Lucinda J Berglund and Stephen S. M. Wong and D. Sean Riminton and Stephen Adelstein and Stuart G Tangye},
  journal={Clinical and experimental immunology},
  volume={157 3},
Common variable immunodeficiency (CVID) is a B cell immunodeficiency disorder characterized frequently by failure of memory B cell development and antibody secretion. A unifying cellular pathogenesis for CVID has not been forthcoming, but given the immunoregulatory role of invariant NK (iNK) T cells and their absence in several other immunodeficiencies, we quantified these cells in the blood of 58 CVID patients. There was a marked decrease in the proportion of iNK T cells in CVID patients… CONTINUE READING


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