Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles

@article{Amigorena1995InvariantCC,
  title={Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles},
  author={S{\'e}bastian Amigorena and Paul Webster and James R. Drake and John Newcomb and Peter Cresswell and Ira Mellman},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={1729 - 1741}
}
B lymphocytes contain a novel population of endocytic vesicles involved in the transport of newly synthesized major histocompatibility complex (MHC) class II alpha beta chains and alpha beta peptide complexes to the cell surface. We now present evidence that these class II-enriched vesicles (CIIV) are also likely to be a site for the loading of immunogenic peptides onto MHC molecules. We used the serine protease inhibitor leupeptin to accumulate naturally occurring intermediates in the… CONTINUE READING

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