Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells.

@article{Li2009InvariantTR,
  title={Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells.},
  author={Xiangming Li and Takayuki Shiratsuchi and Guangwu Chen and Paolo Dellabona and Giulia Casorati and Richard Franck and Moriya Tsuji},
  journal={Journal of immunology},
  year={2009},
  volume={183 7},
  pages={4415-21}
}
C-glycoside analogues of alpha-galactosylceramide were shown to activate both human and mouse invariant NKT (iNKT) cells. Among these analogues, GCK152, which has an aromatic ring in the acyl chain, exhibited a stronger stimulatory activity against human iNKT cells and a much weaker activity against murine iNKT cells than GCK127 that has an almost identical fatty acyl chain as alpha-galactosylceramide. In this study, we have found that invariant TCR (invTCR) expressed by iNKT cells, but not… CONTINUE READING

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Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant.

Proceedings of the National Academy of Sciences of the United States of America • 2010

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