Invariant NKT cells recognize glycolipids from pathogenic Gram-positive bacteria

Abstract

Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the… (More)
DOI: 10.1038/ni.2096

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