Invariant NKT cells inhibit development of the Th17 lineage.

  title={Invariant NKT cells inhibit development of the Th17 lineage.},
  author={Lennart T. Mars and Luiza M. Araujo and Philippe Kerschen and S{\'e}verine Diem and Elvire A. Bourgeois and Linh Pham Van and Nad{\`e}ge Carri{\'e} and Michel Dy and Roland S Liblau and Andr{\'e} Herbelin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 15},
T cells differentiate into functionally distinct effector subsets in response to pathogen encounter. Cells of the innate immune system direct this process; CD1d-restricted invariant natural killer T (iNKT) cells, for example, can either promote or inhibit Th(1) and Th(2) responses. Recently, a new subset of CD4(+) T helper cells, called Th(17), was identified that is implicated in mucosal immunity and autoimmune disorders. To investigate the influence of iNKT cells on the differentiation of na… CONTINUE READING


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