Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.


Invariant NKT (iNKT) cells are innate lymphocytes that respond to glycolipids presented by the MHC class Ib molecule CD1d and are rapidly activated to produce large quantities of cytokines and chemokines. iNKT cell development uniquely depends on interactions between double-positive thymocytes that provide key homotypic interactions between signaling… (More)
DOI: 10.4049/jimmunol.1601369