Invariant Chain Induces B Cell Maturation by Activating a TAFII105-NF-κB-dependent Transcription Program

@inproceedings{Matza2001InvariantCI,
  title={Invariant Chain Induces B Cell Maturation by Activating a TAFII105-NF-κB-dependent Transcription Program},
  author={Didi Matza and Orit Wolstein and Rivka Dikstein and Idit Shachar},
  year={2001}
}
Abstract Early stages of B cell development occur in the bone marrow, resulting in formation of immature B cells. From there these immature cells migrate to the spleen where they differentiate to mature cells. This final maturation step is crucial for the B cells to become responsive to antigens and to participate in the immune response. Recently, invariant chain (Ii), a major histocompatibility complex class II chaperone, as well as the transcription factors c-Rel and p65/RelA, were found to… CONTINUE READING