Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis.

@article{Leong2014InvadopodiaAR,
  title={Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis.},
  author={Hon S Leong and Amy E. Robertson and Konstantin Stoletov and Sean J. Leith and Curtis A Chin and Andrew E Chien and M. Nicole Hague and Amber L Ablack and Katia Carmine-Simmen and Victor A. McPherson and Carl O. Postenka and Eva Ann Turley and Sara A Courtneidge and Ann F. Chambers and John D. Lewis},
  journal={Cell reports},
  year={2014},
  volume={8 5},
  pages={1558-70}
}
Tumor cell extravasation is a key step during cancer metastasis, yet the precise mechanisms that regulate this dynamic process are unclear. We utilized a high-resolution time-lapse intravital imaging approach to visualize the dynamics of cancer cell extravasation in vivo. During intravascular migration, cancer cells form protrusive structures identified as invadopodia by their enrichment of MT1-MMP, cortactin, Tks4, and importantly Tks5, which localizes exclusively to invadopodia. Cancer cells… CONTINUE READING