Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury.

@article{Viebahn2010InvadingMP,
  title={Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury.},
  author={Cornelia S. Viebahn and Volker Benseler and Lauren Holz and Caryn Elsegood and Michelle Vo and Patrick Bertolino and Ruth Ganss and George C.T. Yeoh},
  journal={Journal of hepatology},
  year={2010},
  volume={53 3},
  pages={
          500-7
        }
}
BACKGROUND & AIMS Although a strong association between liver progenitor cells (LPCs) and inflammation exists in many chronic liver diseases, the exact role of the immune system in LPC-mediated hepatic regeneration remains unclear. A number of pro-inflammatory factors were identified in cytokine knockout mice in which the LPC response was attenuated but neither the mechanism nor the producing cells are known. METHODS To identify the critical immune cells and cytokines required in the LPC… CONTINUE READING
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