Inv Estiga Ting Evolutionary Lines of Lea St

  title={Inv Estiga Ting Evolutionary Lines of Lea St},
  author={K. Vander Vel den O. Eu l enstei n},
  • K. Vander Vel den O. Eu l enstei n
  • Published 2001
We present a polynomial time algorithm for estimating optimal HP sequences that fold to a specified target protein conformation based on Sun et al’s Grand Canonical (GC) model. Application of the algorithm to related proteins taken from the PDB allows us to explore the nature of the protein genotype:phenotype map. Results suggest: (1) that the GC model captures important biological aspects of the mapping between protein sequences and their corresponding structures, and (2) the set of sequences… CONTINUE READING

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