Intussusceptive angiogenesis: Its emergence, its characteristics, and its significance

@article{Burri2004IntussusceptiveAI,
  title={Intussusceptive angiogenesis: Its emergence, its characteristics, and its significance},
  author={Peter H. Burri and Ruslan Hlushchuk and Valentin G. Djonov},
  journal={Developmental Dynamics},
  year={2004},
  volume={231}
}
This review shall familiarize the reader with the various aspects of intussusceptive angiogenesis (IA). The basic event in IA is the formation of transvascular tissue pillars. Depending on location, timing, and frequency of pillar emergence, the IA process has different outcomes. In capillaries, a primary IA function is to expand the capillary bed in size and complexity (intussusceptive microvascular growth). It represents an alternative to capillary sprouting. Highly ordered pillar formation… 

Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling

Molecular control of IA has so far not been unequivocally elucidated but interplay among several factors is probably involved, and future investigations are strongly encouraged to focus on interactions among angiogenic growth factors, angiopoetins, and related receptors.

Intussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis.

The concept of IA and IL as the mechanism by which blood and lymphatic vessels split, expand and remodel through transluminal pillar formations are considered, as well as differences and complementarity between vessel sprouting and intussusception.

Intussusceptive Pillar Formation in Developing Porcine Glomeruli

This study shows ECM presence in a mature intussusceptive pillar without any perivascular cell involvement in the structure, leading to the hypothesis that ECM deposition precedes the participation of these cells in the formation of intraluminal pillars during IA in porcine metanephric glomerular capillaries.

Intussusceptive Angiogenesis and Peg–Socket Junctions between Endothelial Cells and Smooth Muscle Cells in Early Arterial Intimal Thickening

Angiogenesis and vessel regression play an important role in AIT development in the conditions studied, with participation of intussusceptive angiogenesis during the formation and regression of a provisional microvasculature and with morphologic interrelation between ECs and VSMCs.

Microvascular endowment in the developing chicken embryo lung.

Temporospatial interplay between sprouting and intussusceptive angiogenesis fabricates a unique vascular angioarchitecture that contributes to the establishment of a highly efficient gas exchange system characteristic of the avian lung.

Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization

Findings indicate that sprouting and intussusceptive angiogenesis are pivotal mechanisms in adult lung alveolarization after pneumonectomy, and various forms of developmental neoalveolarizations may also be considered to contribute in compensatory lung regeneration.

Ultrastructural Study of Platelet Behavior and Interrelationship in Sprouting and Intussusceptive Angiogenesis during Arterial Intimal Thickening Formation

In sprouting and intussusceptive angiogenesis and vessel regression during IT formation, sequential ultrastructural findings on platelet behavior and relationships are contributed, which can be the basis for further studies using other procedures.

Morphological characterization of sprouting and intussusceptive angiogenesis by SEM in oral squamous cell carcinoma.

The method of corrosion associated with scanning electron microscopy proved to be an excellent tool to study the two types of angiogenesis in oral squamous cell carcinoma induced in hamster buccal pouch.

Techniques used to assess intussusceptive angiogenesis: A systematic review

The goal of this systematic review was to investigate which techniques are being used to identify intraluminal pillars and to formulate important points to keep in mind when studying IA.
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  • Biology
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The theory of bifurcating vascular systems predicts vessel diameters that are related to optimality criteria like minimization of pumping energy or of building material. However, mechanisms for

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Intussusception appears to be a principle of growth appertaining to many vascular systems, namely, those of the eye, submandibular gland, heart, liver, stomach, small and large intestine, trachea, kidney, uterus and ovary.

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Intussusception, i.e., transluminal pillar formation, is one essential mechanism for growth, arborization, bifurcation remodeling, and pruning in angiogenesis.
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