Intussusceptive angiogenesis: Its emergence, its characteristics, and its significance

  title={Intussusceptive angiogenesis: Its emergence, its characteristics, and its significance},
  author={Peter H. Burri and Ruslan Hlushchuk and Valentin G. Djonov},
  journal={Developmental Dynamics},
This review shall familiarize the reader with the various aspects of intussusceptive angiogenesis (IA). The basic event in IA is the formation of transvascular tissue pillars. Depending on location, timing, and frequency of pillar emergence, the IA process has different outcomes. In capillaries, a primary IA function is to expand the capillary bed in size and complexity (intussusceptive microvascular growth). It represents an alternative to capillary sprouting. Highly ordered pillar formation… 

Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling

Molecular control of IA has so far not been unequivocally elucidated but interplay among several factors is probably involved, and future investigations are strongly encouraged to focus on interactions among angiogenic growth factors, angiopoetins, and related receptors.

Intussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis.

The concept of IA and IL as the mechanism by which blood and lymphatic vessels split, expand and remodel through transluminal pillar formations are considered, as well as differences and complementarity between vessel sprouting and intussusception.

Intussusceptive Pillar Formation in Developing Porcine Glomeruli

This study shows ECM presence in a mature intussusceptive pillar without any perivascular cell involvement in the structure, leading to the hypothesis that ECM deposition precedes the participation of these cells in the formation of intraluminal pillars during IA in porcine metanephric glomerular capillaries.

Intussusceptive Angiogenesis and Peg–Socket Junctions between Endothelial Cells and Smooth Muscle Cells in Early Arterial Intimal Thickening

Angiogenesis and vessel regression play an important role in AIT development in the conditions studied, with participation of intussusceptive angiogenesis during the formation and regression of a provisional microvasculature and with morphologic interrelation between ECs and VSMCs.

Microvascular endowment in the developing chicken embryo lung.

Temporospatial interplay between sprouting and intussusceptive angiogenesis fabricates a unique vascular angioarchitecture that contributes to the establishment of a highly efficient gas exchange system characteristic of the avian lung.

Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization

Findings indicate that sprouting and intussusceptive angiogenesis are pivotal mechanisms in adult lung alveolarization after pneumonectomy, and various forms of developmental neoalveolarizations may also be considered to contribute in compensatory lung regeneration.

Ultrastructural Study of Platelet Behavior and Interrelationship in Sprouting and Intussusceptive Angiogenesis during Arterial Intimal Thickening Formation

In sprouting and intussusceptive angiogenesis and vessel regression during IT formation, sequential ultrastructural findings on platelet behavior and relationships are contributed, which can be the basis for further studies using other procedures.

Morphological characterization of sprouting and intussusceptive angiogenesis by SEM in oral squamous cell carcinoma.

The method of corrosion associated with scanning electron microscopy proved to be an excellent tool to study the two types of angiogenesis in oral squamous cell carcinoma induced in hamster buccal pouch.

Techniques used to assess intussusceptive angiogenesis: A systematic review

The goal of this systematic review was to investigate which techniques are being used to identify intraluminal pillars and to formulate important points to keep in mind when studying IA.



Intussusceptive angiogenesis: its role in embryonic vascular network formation.

Transcapillary pillar formation, ie, intussusception, is a central and probably widespread process, which plays a role not only in capillary network growth and expansion (intussusceptive microvascular growth), but also in vascular plexus remodeling and tree formation (intussedusceptive arborization).

Vascular remodeling by intussusceptive angiogenesis

Intussusception appears to be triggered immediately after the formation of the primitive capillary plexus by vasculogenesis or sprouting, and the advantage of this mechanism of growth over sprouting is that blood vessels are generated more rapidly in an energetically and metabolically more economic manner.

Intussusceptive arborization contributes to vascular tree formation in the chick chorio-allantoic membrane

It is concluded that after the early sprouting phase, the process of intussusception is the basic mechanism of CAM vascularization and leads to capillary network growth and expansion (IMG) and, at the same time, to feed vessel formation with several branching generations (IAR).

Optimality in the developing vascular system: Branching remodeling by means of intussusception as an efficient adaptation mechanism

  • V. DjonovH. KurzP. Burri
  • Biology
    Developmental dynamics : an official publication of the American Association of Anatomists
  • 2002
The theory of bifurcating vascular systems predicts vessel diameters that are related to optimality criteria like minimization of pumping energy or of building material. However, mechanisms for

Intussusceptive microvascular growth: a common alternative to capillary sprouting.

Intussusception appears to be a principle of growth appertaining to many vascular systems, namely, those of the eye, submandibular gland, heart, liver, stomach, small and large intestine, trachea, kidney, uterus and ovary.

Implementation of intussusceptive microvascular growth in the chicken chorioallantoic membrane (CAM).

A further mechanism of IMG is reported in the chicken CAM: tissue pillars form by splitting of larger interstitial tissue structures and intercapillary walls located between neighboring capillary segments which will consecutively fuse.

Implementation of intussusceptive microvascular growth in the chicken chorioallantoic membrane (CAM): 1. pillar formation by folding of the capillary wall.

The first of several modes of its implementation can now be presented in the CAM by in vivo video microscopy and analyses of light and electron microscopic serial sections: Cores of tissue pillars containing collagen fibrils ensheathed by extensions of endothelial-like cells will form within the tips of vertically running tissue folds that project into the capillary lumen.

Quantitative study of intussusceptive capillary growth in the chorioallantoic membrane (CAM) of the chicken embryo.

By means of morphometric analysis, it is shown that CAM angiogenesis undergoes three phases of development, and care has to be taken not to misinterpret normal age-dependent alterations of the CAM vascular architecture as specific responses to tested agents.

Evidence for intussusceptive capillary growth in the chicken chorio-allantoic membrane (CAM)

The observations confirm that the chicken chorio-allantoic membrane is a very suitable material for the in vivo investigation of intussusceptive capillary growth.

Angiogenesis and vascular remodeling by intussusception: from form to function.

  • H. KurzP. BurriV. Djonov
  • Biology
    News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
  • 2003
Intussusception, i.e., transluminal pillar formation, is one essential mechanism for growth, arborization, bifurcation remodeling, and pruning in angiogenesis.