Introns in UTRs: Why we should stop ignoring them

  title={Introns in UTRs: Why we should stop ignoring them},
  author={Alicia A. Bicknell and Can Cenik and H. N. Chua and F. Roth and M. Moore},
  • Alicia A. Bicknell, Can Cenik, +2 authors M. Moore
  • Published 2012
  • Biology, Medicine
  • BioEssays
  • Although introns in 5′‐ and 3′‐untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3′‐UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense‐mediated decay (NMD). Nonetheless, recent findings indicate that 5′‐ and 3′‐UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these… CONTINUE READING
    92 Citations
    Intron retention in mRNA: No longer nonsense
    • 116
    Control of mRNA Stability in Fungi by NMD, EJC and CBC Factors Through 3′UTR Introns
    • 20
    • PDF
    Genome-Wide Identification and Characterization of UTR-Introns of Citrus sinensis
    • Highly Influenced
    • PDF
    Untranslated Parts of Genes Interpreted: Making Heads or Tails of High‐Throughput Transcriptomic Data via Computational Methods
    • 7
    • PDF


    How introns influence and enhance eukaryotic gene expression.
    • 631
    • PDF
    Intron size, abundance, and distribution within untranslated regions of genes.
    • 159
    • PDF
    Genome-wide functional analysis of human 5' untranslated region introns
    • 61
    • PDF
    Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells.
    • 403
    • PDF
    Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes
    • 66
    • PDF
    The Origins, Evolution, and Functional Potential of Alternative Splicing in Vertebrates
    • 64
    • PDF