Introns are mediators of cell response to starvation

@article{Parenteau2019IntronsAM,
  title={Introns are mediators of cell response to starvation},
  author={J. Parenteau and Laurine Maignon and M{\'e}lodie Berthoumieux and M. Catala and Vanessa Gagnon and S. Abou Elela},
  journal={Nature},
  year={2019},
  volume={565},
  pages={612-617}
}
  • J. Parenteau, Laurine Maignon, +3 authors S. Abou Elela
  • Published 2019
  • Biology, Medicine
  • Nature
  • Introns are ubiquitous features of all eukaryotic cells. Introns need to be removed from nascent messenger RNA through the process of splicing to produce functional proteins. Here we show that the physical presence of introns in the genome promotes cell survival under starvation conditions. A systematic deletion set of all known introns in budding yeast genes indicates that, in most cases, cells with an intron deletion are impaired when nutrients are depleted. This effect of introns on growth… CONTINUE READING
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