Introns are mediators of cell response to starvation

  title={Introns are mediators of cell response to starvation},
  author={J. Parenteau and Laurine Maignon and M{\'e}lodie Berthoumieux and M. Catala and Vanessa Gagnon and S. Abou Elela},
  • J. Parenteau, Laurine Maignon, +3 authors S. Abou Elela
  • Published 2019
  • Biology, Medicine
  • Nature
  • Introns are ubiquitous features of all eukaryotic cells. Introns need to be removed from nascent messenger RNA through the process of splicing to produce functional proteins. Here we show that the physical presence of introns in the genome promotes cell survival under starvation conditions. A systematic deletion set of all known introns in budding yeast genes indicates that, in most cases, cells with an intron deletion are impaired when nutrients are depleted. This effect of introns on growth… CONTINUE READING
    62 Citations

    Figures and Topics from this paper

    Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs
    • 2
    Control of Translation at the Initiation Phase During Glucose Starvation in Yeast
    • 6
    • PDF
    Spliceosomal Introns: Features, Functions, and Evolution
    • 1
    The changing paradigm of intron retention: regulation, ramifications and recipes
    • 13
    • PDF
    Regulation of ribosomal protein genes: An ordered anarchy.
    Introns: Good Day Junk Is Bad Day Treasure.
    • 3


    Deletion of many yeast introns reveals a minority of genes that require splicing for function.
    • 111
    • PDF
    Introns: The Functional Benefits of Introns in Genomes
    • 89
    • PDF
    The intronome of budding yeasts.
    • 59
    Intron Evolution in Saccharomycetaceae
    • 36
    • PDF
    The Transcriptional Landscape of the Yeast Genome Defined by RNA Sequencing
    • 2,298
    • PDF