Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs

@article{Wang2011IntronicPI,
  title={Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs},
  author={Danxin Wang and Yang Guo and Steven A. Wrighton and Glen E. Cooke and Wolfgang Sadee},
  journal={The Pharmacogenomics Journal},
  year={2011},
  volume={11},
  pages={274-286}
}
Cytochrome P450 3A4 (CYP3A4) metabolizes ∼50% of all clinically used drugs. Although CYP3A4 expression varies widely between individuals, the contribution of genetic factors remains uncertain. In this study, we measured allelic CYP3A4 heteronuclear RNA (hnRNA) and mRNA expression in 76 human liver samples heterozygous for at least one of eight marker SNPs and found marked allelic expression imbalance (1.6–6.3-fold) in 10/76 liver samples (13%). This was fully accounted for by an intron 6 SNP… CONTINUE READING
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