Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways.

@article{Cao2010IntronicMF,
  title={Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways.},
  author={Guojun Cao and Baochun Huang and Zhaohui Liu and Jiyan Zhang and Hua Xu and Wei Xia and Jie Li and Shaohua Li and Liucun Chen and Hongmei Ding and Qiang Zhao and Ming Fan and Beifen Shen and Ningsheng Shao},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={396 4},
  pages={978-82}
}
miR-301 is localized in the first intron of ska2, whose function has not been clarified. Here, a new circuit model in which intronic miR-301 regulates the transcription and function of its host gene through a feedback mechanism has been described. Our results showed that blocking of miR-301 in A549 cells leads to a decrease in the expression of the host gene, ska2. Further analysis showed that miR-301 targets MEOX2 to affect the ERK/CREB pathway. CREB directly regulates the expression of the… CONTINUE READING

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