Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription

@inproceedings{Alotaibi2010IntronicEI,
  title={Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription},
  author={Hani Alotaibi and Elif Cankaya Yaman and Domenico Salvatore and Valeria Di Dato and Pelin Telkoparan and Roberto Di Lauro and Uygar Halis Tazebay},
  booktitle={Nucleic acids research},
  year={2010}
}
Activity of the sodium/iodide symporter (NIS) in lactating breast is essential for iodide (I(-)) accumulation in milk. Significant NIS upregulation was also reported in breast cancer, indicating a potential use of radioiodide treatment. All-trans-retinoic acid (tRA) is a potent ligand that enhances NIS expression in a subset of breast cancer cell lines and in experimental breast cancer models. Indirect tRA stimulation of NIS in breast cancer cells is very well documented; however, direct… CONTINUE READING