Intronic deletion affecting a negative regulatory region of TP73 is related to breast and colorectal carcinomas.

Abstract

The TP73 gene encodes a nuclear protein that has high homology with TP53. TP73 is rarely mutated in human cancer. The presence of a 1-kb regulatory fragment within the first intron of TP73 was recently reported. This fragment exerts silencer activity on TP73 mediated by ZEB. We searched for possible mutations in this negative regulatory region in 45… (More)

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Cite this paper

@article{Pea2004IntronicDA, title={Intronic deletion affecting a negative regulatory region of TP73 is related to breast and colorectal carcinomas.}, author={Cristina Gehibie Reynaga Pe{\~n}a and Jos{\'e} M. Garc{\'i}a and G Dom{\'i}nguez and J Natalino M Silva and Vanesa Quiroga Garc{\'i}a and Enric Carcereny and Javier Vargas and Mariano Provencio and Pilar Espa{\~n}a and F elix Bonilla}, journal={Genes, chromosomes & cancer}, year={2004}, volume={39 3}, pages={257-62} }