Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing

Abstract

hnRNP A/B proteins modulate the alternative splicing of several mammalian and viral pre-mRNAs, and are typically viewed as proteins that enforce the activity of splicing silencers. Here we show that intronic hnRNP A/B-binding sites (ABS) can stimulate the in vitro splicing of pre-mRNAs containing artificially enlarged introns. Stimulation of in vitro… (More)

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Cite this paper

@article{MartinezContreras2006IntronicBS, title={Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing}, author={Rebeca Martinez-Contreras and Jean-François Fisette and Faiz-ul Hassan Nasim and Richard O. Madden and M{\'e}lanie Cordeau and Benoit Chabot}, journal={PLoS Biology}, year={2006}, volume={4}, pages={860 - 921} }