Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.

@article{Moran2008IntronRA,
  title={Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.},
  author={Yehu Moran and Hagar Weinberger and Adam M. Reitzel and James C. Sullivan and Roy Kahn and Dalia Gordon and John R. Finnerty and Michael Gurevitz},
  journal={Journal of molecular biology},
  year={2008},
  volume={380 3},
  pages={437-43}
}
Sea anemones use an arsenal of peptide neurotoxins accumulated in special stinging cells (nematocytes) for defense and predation. Intriguingly, genomic analysis of Nematostella vectensis revealed only a single toxin, Nv1 (N. vectensis toxin 1), encoded by multiple extremely conserved genes. We examined the toxic potential of Nv1 and whether it is produced by the three developmental stages (embryo, planula, and polyp) of Nematostella. Nv1 was expressed in recombinant form and, similarly to Type… CONTINUE READING

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