Intron loss and gain in Drosophila.

@article{CoulombeHuntington2007IntronLA,
  title={Intron loss and gain in Drosophila.},
  author={Jasmin Coulombe-Huntington and Jacek Majewski},
  journal={Molecular biology and evolution},
  year={2007},
  volume={24 12},
  pages={2842-50}
}
Although introns were first discovered almost 30 years ago, their evolutionary origin remains elusive. In this work, we used multispecies whole-genome alignments to map Drosophila melanogaster introns onto 10 other fully sequenced Drosophila genomes. We were able to find 1,944 sites where an intron was missing in one or more species. We show that for most (>80%) of these cases, there is no leftover intronic sequence or any missing exonic sequence, indicating exact intron loss or gain events. We… CONTINUE READING

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