Intron Retention in mRNA Encoding Ancillary Subunit of Insect Voltage-Gated Sodium Channel Modulates Channel Expression, Gating Regulation and Drug Sensitivity

@inproceedings{Bourdin2013IntronRI,
  title={Intron Retention in mRNA Encoding Ancillary Subunit of Insect Voltage-Gated Sodium Channel Modulates Channel Expression, Gating Regulation and Drug Sensitivity},
  author={C{\'e}line Michelle Bourdin and B{\'e}n{\'e}dicte Moignot and Lingxin Wang and Laurence Murillo and Marjorie Juchaux and Sophie Quinchard and Bruno Lapied and Nathalie C. Gu{\'e}rineau and Ke Dong and Christian Legros},
  booktitle={PloS one},
  year={2013}
}
Insect voltage-gated sodium (Nav) channels are formed by a well-known pore-forming α-subunit encoded by para-like gene and ancillary subunits related to TipE from the mutation "temperature-induced-paralysis locus E." The role of these ancillary subunits in the modulation of biophysical and pharmacological properties of Na(+) currents are not enough documented. The unique neuronal ancillary subunit TipE-homologous protein 1 of Drosophila melanogaster (DmTEH1) strongly enhances the expression of… CONTINUE READING
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