Intron 1 elements promote erythroid-specific GATA-1 gene expression.

  title={Intron 1 elements promote erythroid-specific GATA-1 gene expression.},
  author={Dhaya Seshasayee and Justin N Geiger and Peter C. W. Gaines and Don M. Wojchowski},
  journal={The Journal of biological chemistry},
  volume={275 30},
The zinc finger protein GATA-1 functions in a concentration-dependent fashion to activate the transcription of erythroid and megakaryocytic genes. Less is understood, however, regarding factors that regulate the GATA-1 gene. Presently elements within intron 1 are shown to markedly affect its erythroid-restricted transcription. Within a full-length 6. 8-kilobase GATA-1 gene construct (G6.8-Luc) the deletion of a central subdomain of intron 1 inhibited transcription >/=10-fold in transiently… CONTINUE READING