Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer.

@article{Han2007Intron1C,
  title={Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer.},
  author={S. -M. Han and Yoon Kyung Jeon and Kyung Hun Lee and Bhumsuk Keum and Pil Gyu Hwang and Do-youn Oh and Se-Hoon Lee and Dong-Wan Kim and Seock-Ah Im and Doo Hyun Chung and Dae Seog DS Heo and Yung-jue Bang and T. -Y. Kim},
  journal={Pharmacogenetics and genomics},
  year={2007},
  volume={17 5},
  pages={313-9}
}
OBJECTIVE Limited availability of tumoral tissue in non-small-cell lung cancer and presence of epidermal growth factor receptor mutation-independent responses call for investigation of other molecular predictive marker of gefitinib responsiveness. Therefore, CA repeat polymorphism in intron 1 was analyzed for its association with gefitinib responsiveness together with epidermal growth factor receptor mutation in Korean patients. PATIENTS AND METHODS For 86 advanced non-small-cell lung cancer… CONTINUE READING

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