Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors.

@article{Dannemann2016IntrogressionON,
  title={Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors.},
  author={Michael Dannemann and Aida M. Andr{\'e}s and Janet Kelso},
  journal={American journal of human genetics},
  year={2016},
  volume={98 1},
  pages={
          22-33
        }
}
Pathogens and the diseases they cause have been among the most important selective forces experienced by humans during their evolutionary history. Although adaptive alleles generally arise by mutation, introgression can also be a valuable source of beneficial alleles. Archaic humans, who lived in Europe and Western Asia for more than 200,000 years, were probably well adapted to this environment and its local pathogens. It is therefore conceivable that modern humans entering Europe and Western… CONTINUE READING

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