Introgression of Chromosome 13 into the Dahl S Genetic Background Restores Cerebral Artery Dilation in SS-13 Consomic Rats

Abstract

To evaluate the potential role of impaired renin-angiotensin system (RAS) function in contributing to reduced vascular relaxation in Dahl salt sensitive (S) rats, responses to acetylcholine (10-6 mol/L) and hypoxia (PO 2 reduction to 40-45 mm Hg), were determined in isolated middle cerebral arteries of Dahl S rats, Brown Norway (BN) rats, and consomic rats… (More)

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