Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development.

@article{Baranczewski2006IntroductionTI,
  title={Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development.},
  author={Paweł Baranczewski and Andrzej Stańczak and Kathrin Sundberg and Richard Berntsson Svensson and Asa Wallin and Jenny Jansson and Per Garberg and Hans Postlind},
  journal={Pharmacological reports : PR},
  year={2006},
  volume={58 4},
  pages={453-72}
}
Determination of metabolic properties of a new chemical entity (NCE) is one of the most important steps during the drug discovery and development process. Nowadays, in vitro methods are used for early estimation and prediction of in vivo metabolism of NCEs. Using in vitro methods, it is possible to determine the metabolic stability of NCEs as well as the risk for drug-drug interactions (DDIs) related to inhibition and induction of drug metabolic enzymes. Metabolic stability is defined as the… CONTINUE READING

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