Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development.

  title={Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development.},
  author={Paweł Baranczewski and Andrzej Stańczak and Kathrin Sundberg and Richard Berntsson Svensson and Asa Wallin and Jenny Jansson and Per Garberg and Hans Postlind},
  journal={Pharmacological reports : PR},
  volume={58 4},
Determination of metabolic properties of a new chemical entity (NCE) is one of the most important steps during the drug discovery and development process. Nowadays, in vitro methods are used for early estimation and prediction of in vivo metabolism of NCEs. Using in vitro methods, it is possible to determine the metabolic stability of NCEs as well as the risk for drug-drug interactions (DDIs) related to inhibition and induction of drug metabolic enzymes. Metabolic stability is defined as the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 64 extracted citations

Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. Part 5.

European journal of medicinal chemistry • 2015
View 4 Excerpts
Highly Influenced

Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 2016
View 7 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 102 references

Can the pharmaceutical industry reduce attrition rates?

Nature Reviews Drug Discovery • 2004
View 10 Excerpts
Highly Influenced

Mechanism-based enzyme inactivators.

Methods in enzymology • 1995
View 4 Excerpts
Highly Influenced

Strategies for using in vitro screens in drug metabolism.

Drug discovery today • 2004
View 4 Excerpts
Highly Influenced

Biotransformation of xenobiotics in the fetus.

Pharmacology & therapeutics • 1980
View 4 Excerpts
Highly Influenced

A critical evaluation of experi- mental designs used in reports of mechanism based en- zyme inhibition (MBI) studies and the assessment of their implications for in vitro-in vivo extrapolation

F Ghanbari, K Rowland Yeo, MS Lennard, GT Tucker, A Rostami-Hodjegan
Drug Metab Rev, • 2006
View 2 Excerpts

The prediction of human

RS Obach, JG Baxter, +4 authors DJ Rance
Pharmacological Reports, • 2006
View 1 Excerpt

In vitro assays: crystal balls or random guesses

N Plant
Drug Discov Today, • 2005
View 1 Excerpt

Mecha - nismbased inactivation of human cytochrome P 4502 C 8 by drugs in vitro

TM Polasek, DJ Elliot, BC Lewis, JO Miners
Drug Discov Today • 2005

Similar Papers

Loading similar papers…