Introduction to clinical toxicology

@inproceedings{Baud2020IntroductionTC,
  title={Introduction to clinical toxicology},
  author={Fr{\'e}d{\'e}ric Joseph Baud and Pascal Houz{\'e}},
  year={2020}
}
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Artificial Intelligence in Clinical Toxicology

References

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TLDR
Variability between organophosphorus insecticides results in variable speed of poisoning onset, severity, clinical toxidrome, and case fatality, and more effort is required to test treatments in adequately powered studies.
Toxicodynetics in nordiazepam and oxazepam overdoses.
An epidemic of dystonic reactions in central Africa.
Pharmacokinetics and toxicodynamics of pralidoxime effects on paraoxon-induced respiratory toxicity.
TLDR
Insight is provided into the role of oxime-rescue of paraoxon-induced toxicity, and the final PK-TD model might prove useful in optimizing the design and development of such therapy.
High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice.
TLDR
It is shown that pralidoxime induced a complete but concentration-dependent reversal of paraoxon-induced respiratory toxicity in mice, and the dose dependency of reversal suggests that further studies are needed for assessing plasma concentrations of pralid oxime resulting in reversal of toxicity.
Adolescent with prolonged toxidrome
TLDR
Though bezoar formation is a rare clinical scenario, it is one that toxicologists must consider in patients with clinical courses that persist far beyond expected based on known toxicokinetic principles.
Toxic doses of paraoxon alter the respiratory pattern without causing respiratory failure in rats.
Acute renal failure enhances the antidotal activity of pralidoxime towards paraoxon-induced respiratory toxicity.
Does modulation of organic cation transporters improve pralidoxime activity in an animal model of organophosphate poisoning?*
TLDR
Modulation of organic cation transporter activity increased the plasma pralidoxime concentrations and the antidotal effect of pralid oxime with sustained return within the normal range of respiratory variables in paraoxon-poisoned rats, suggesting a promising approach in an animal model toward the increase in efficiency of pridaloxime.
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