Introduction to clinical toxicology

  title={Introduction to clinical toxicology},
  author={Fr{\'e}d{\'e}ric Joseph Baud and Pascal Houz{\'e}},
1 Citations
Artificial Intelligence in Clinical Toxicology


Toxicodynetics: A new discipline in clinical toxicology.
Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning.
  • M. Eddleston
  • Biology, Medicine
    Annual review of pharmacology and toxicology
  • 2019
Variability between organophosphorus insecticides results in variable speed of poisoning onset, severity, clinical toxidrome, and case fatality, and more effort is required to test treatments in adequately powered studies.
Toxicodynetics in nordiazepam and oxazepam overdoses.
An epidemic of dystonic reactions in central Africa.
Pharmacokinetics and toxicodynamics of pralidoxime effects on paraoxon-induced respiratory toxicity.
Insight is provided into the role of oxime-rescue of paraoxon-induced toxicity, and the final PK-TD model might prove useful in optimizing the design and development of such therapy.
High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice.
It is shown that pralidoxime induced a complete but concentration-dependent reversal of paraoxon-induced respiratory toxicity in mice, and the dose dependency of reversal suggests that further studies are needed for assessing plasma concentrations of pralid oxime resulting in reversal of toxicity.
Adolescent with prolonged toxidrome
Though bezoar formation is a rare clinical scenario, it is one that toxicologists must consider in patients with clinical courses that persist far beyond expected based on known toxicokinetic principles.
Does modulation of organic cation transporters improve pralidoxime activity in an animal model of organophosphate poisoning?*
Modulation of organic cation transporter activity increased the plasma pralidoxime concentrations and the antidotal effect of pralid oxime with sustained return within the normal range of respiratory variables in paraoxon-poisoned rats, suggesting a promising approach in an animal model toward the increase in efficiency of pridaloxime.