Introduction of wild-type p53 enhances thrombospondin-1 expression in human glioma cells.

  title={Introduction of wild-type p53 enhances thrombospondin-1 expression in human glioma cells.},
  author={Hironobu Harada and Kou Nakagawa and Masahiro Saito and Shohei Kohno and Shigeyuki Nagato and Koji Furukawa and Yoshiaki Kumon and Katsuyuki Hamada and Takanori Ohnishi},
  journal={Cancer letters},
  volume={191 1},
Malignant gliomas are distinguished from low-grade gliomas by their intense angiogenesis. In gliomas, p53 is the most frequently altered gene and is involved in the early phase of glioma development. In contrast, homozygous p16 gene deletion is more common in high-grade gliomas. In order to understand the mechanism by which gliomas become more angiogenic during the malignant transformation, we examined the relationship between thrombospondin-1, a negative regulator in angiogenesis, and these… CONTINUE READING

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