Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo.

@article{Arai2000IntroductionOT,
  title={Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo.},
  author={Takashi Arai and Koh Abe and Hiroshi Matsuoka and Mitsuhiro Yoshida and Masahide Mori and Sho Goya and Hiroshi Kida and K. Nishino and Tadashi Osaki and Isao Tachibana and Yasufumi Kaneda and Shizu Hayashi},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={278 5},
  pages={L914-22}
}
Interleukin (IL)-10 has been shown to reduce many inflammatory reactions. We investigated the in vivo effects of IL-10 on a bleomycin-induced lung injury model. Hemagglutinating virus of Japan (HVJ)-liposomes containing a human IL-10 expression vector (hIL10-HVJ) or a balanced salt solution as a control (Cont-HVJ) was intraperitoneally injected into mice on day -3. This was followed by intratracheal instillation of bleomycin (0.8 mg/kg) on day 0. Myeloperoxidase activity of bronchoalveolar… CONTINUE READING

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