Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study

@inproceedings{Dodgen2011IntroductionOT,
  title={Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study},
  author={Tyren Mark Dodgen and Warren E Hochfeld and Heidi Fickl and Sahle M Asfaha and Chrisna Durandt and Paul Rheeder and Britt I Dr{\"o}gem{\"o}ller and Galen E B Wright and Louise Warnich and Christiaan DJ Labuschagne and Antoinette van Schalkwyk and Andrea Gaedigk and Michael Sean Pepper},
  booktitle={BMC Medical Genetics},
  year={2011}
}
Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to inter-individual variability in drug metabolism. Studies on the pharmacogenetics of Cytochrome P450 (CYP) enzymes offer insight into this variability. The objective of this study was to compare the AmpliChip CYP450 Test® (AmpliChip) to alternative genotyping platforms for phenotype prediction of CYP2C19 and CYP2D6 in a representative cohort of the… CONTINUE READING

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Nikoloff DM: DNA microarray technology in the clinical environment: the AmpliChip CYP450 test for CYP2D6 and CYP2C19 genotyping

  • J de Leon, MT Susce, +6 authors G Hillman
  • CNS Spectr
  • 2009
Highly Influential
7 Excerpts

Genetic variants in CYP (−1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity

  • C Dandara, Z Lombard, I Du Plooy, T McLellan, SA Norris, M Ramsay
  • Pharmacogenomics
  • 2011

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