Introduction of replication-competent hepatitis C virus transcripts using a tetracycline-regulable baculovirus delivery system.

Abstract

We have developed a baculovirus delivery system that enables tetracycline-regulated expression of polII-derived hepatitis C virus (HCV) transcripts in hepatocyte-derived cell lines (McCormick et al., 2002). As part of a study to determine whether such transcripts are replication competent, the transcription start site of the tetracycline-regulable promoter… (More)

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