Introduction of protein or DNA delivered via recombinant Salmonella typhimurium into the major histocompatibility complex class I presentation pathway of macrophages.

@article{Catic1999IntroductionOP,
  title={Introduction of protein or DNA delivered via recombinant Salmonella typhimurium into the major histocompatibility complex class I presentation pathway of macrophages.},
  author={Andr{\'e} Catic and Guido Dietrich and Ivaylo Gentschev and W. Goebel and Stefan H. E. Kaufmann and J{\"u}rgen Hess},
  journal={Microbes and infection},
  year={1999},
  volume={1 2},
  pages={
          113-21
        }
}
Recombinant (r) Salmonella typhimurium aroA strains which display the hen egg ovalbumin OVA(257-264) peptide SIINFEKL in secreted form were constructed. In addition, attenuated rS. typhimurium pcDNA-OVA constructs harbouring a eukaryotic expression plasmid encoding complete OVA were used to introduce the immunodominant OVA(257-264) epitope into the major histocompatibility complex (MHC) class I presentation pathway. Both modes of antigen delivery (DNA and protein) by Salmonella vaccine carriers… CONTINUE READING
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