Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis.

@article{Cerrato2001IntroductionOM,
  title={Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis.},
  author={Julie A Cerrato and W. K. Alfred Yung and T J J Liu},
  journal={Neuro-oncology},
  year={2001},
  volume={3 2},
  pages={113-22}
}
Transient expression of the tumor suppressor gene p53 via adenoviral-mediated gene transfer induces apoptosis in glioma cells expressing mutant p53, while causing cell cycle arrest in cells with wild-type p53. To determine whether a change in p53 status of a wild-type p53-expressing cell line such as U-87 MG would alter its apoptotic resistant phenotype in response to Ad-p53 infection, we generated cell lines U-87-175.4 and U-87-175.13 via retroviral-mediated gene transfer of the p53 (175H… CONTINUE READING

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Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

Proceedings of the National Academy of Sciences of the United States of America • 1997
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