Introduction of metastatic heterogeneity by short-term in vivo passage of a cloned transformed cell line.

@article{Talmadge1979IntroductionOM,
  title={Introduction of metastatic heterogeneity by short-term in vivo passage of a cloned transformed cell line.},
  author={James E Talmadge and Jean R. Starkey and William C. Davis and Arthur L. Cohen},
  journal={Journal of supramolecular structure},
  year={1979},
  volume={12 2},
  pages={227-43}
}
An experimental system for the study of metastasis has been developed using an epithelioid cell line of hepatic origin which had previously been chemically transformed in vitro. These metastatic cells were studied in the syngeneic rat strain. The cloned parent cell line metastasizes only to the lungs following intravenous, subcutaneous, or intraperitoneal injection. The metastatic phenotype is stable during in vitro passage, and subclones from the parent clone have a metastatic capacity… CONTINUE READING