Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies.

@article{Iizuka1998IntroductionOA,
  title={Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies.},
  author={Jyunpei Iizuka and Yoko U Katagiri and Norihiro Tada and Masami Murakami and Tetsurou Ikeda and Mayumi Eliza Otsuka Sato and Katsuiku Hirokawa and Seiji Okada and Masahiko Hatano and Takeshi Tokuhisa and Toshimitsu Uede},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1998},
  volume={78 12},
  pages={1523-33}
}
Osteopontin (OPN) is an Arg-Gly-Asp-containing phosphoprotein that is secreted by activated T cells. The concentration of serum OPN protein is elevated in autoimmune-prone MRL-lpr mice as well as in patients with systemic lupus erythematosus. Previously, it was shown that OPN induces the polyclonal activation of B cells, resulting in the augmented production of immunoglobulin, indicating that OPN plays some role in the development of autoimmune disease. However, the link between OPN and… CONTINUE READING