Introduction of a xenogeneic gene via hematopoietic stem cells leads to specific tolerance in a rhesus monkey model.

@article{Heim2000IntroductionOA,
  title={Introduction of a xenogeneic gene via hematopoietic stem cells leads to specific tolerance in a rhesus monkey model.},
  author={Dominik A Heim and Yutaka Hanazono and N. H. V. Krishna Giri and Tong Wu and Richard Childs and Stephanie E Sellers and Linda Mesler Muul and Brian A Agricola and Mark E. Metzger and Robert E Donahue and John F. Tisdale and Cynthia E Dunbar},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2000},
  volume={1 6},
  pages={533-44}
}
Host immune responses against foreign transgenes may be a major obstacle to successful gene therapy. To clarify the impact of an immune response to foreign transgene products on the survival of genetically modified cells, we studied the in vivo persistence of cells transduced with a vector expressing a foreign transgene compared to cells transduced with a nonexpressing vector in the clinically predictive rhesus macaque model. We constructed retroviral vectors containing the neomycin… CONTINUE READING

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