Introduction of a rabbit β-globin gene into the mouse germ line

@article{Costantini1981IntroductionOA,
  title={Introduction of a rabbit β-globin gene into the mouse germ line},
  author={F. Costantini and E. Lacy},
  journal={Nature},
  year={1981},
  volume={294},
  pages={92-94}
}
The introduction of cloned foreign genes into cultured mammalian cells1–7 has been used to identify DNA sequences required for correct transcription in vivo8–10. It is not clear, however, to what extent these systems will be useful for an analysis of the sequences necessary for tissue-specific gene expression. A more appropriate approach for such an analysis might be the production of mice that contain a cloned foreign gene in all their cells, throughout development. This could be accomplished… Expand
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