Introduction of H-antigens into oligosaccharides and sugar chains of glycoproteins using highly efficient 1,2-α-l-fucosynthase.

@article{Sugiyama2016IntroductionOH,
  title={Introduction of H-antigens into oligosaccharides and sugar chains of glycoproteins using highly efficient 1,2-α-l-fucosynthase.},
  author={Yuta Sugiyama and Aina Gotoh and Toshihiko Katoh and Yuji Honda and Erina Yoshida and Shin Kurihara and Hisashi Ashida and Hidehiko Kumagai and Kenji Yamamoto and Motomitsu Kitaoka and Takane Katayama},
  journal={Glycobiology},
  year={2016},
  volume={26 11},
  pages={1235-1247}
}
Fucα1-2 Gal linkages, or H-antigens, constitute histo-blood group antigens and are involved in various physiological processes. In addition, recent studies have shown that the H-antigen-containing glycans play an important role, not only in establishing harmonious relationship between gut microbes and the host, but also in preventing gut dysbiosis-related diseases. Therefore, development of an efficient method for introducing Fuc residue at Gal residue at the nonreducing end of glycans via α-(1… CONTINUE READING
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