Corpus ID: 6089867

Introduction Arctigenin induces apoptosis in colon cancer cells through ROS / p 38 MAPK pathway

  title={Introduction Arctigenin induces apoptosis in colon cancer cells through ROS / p 38 MAPK pathway},
  author={Qing-chun Li and Yun Liang and Yuan Tian and Guang-rui Hu},
of arctigenin, plant lignin, was evaluated on human colon cancer cell line HT-29. Furthermore, attempts were made to explore the signaling mechanism which may be responsible for its effect. Methods: Cell growth inhibition was assessed by MTT and LDH assays. Flow cytometric analysis was performed to determine cell arrest in the cell cycle phase and apoptosis. Furthermore, to confirm the apoptotic activity of arctigenin, caspase-9 and -3 activities analysis was performed. The levels of reactive… Expand
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