Introduction: sirtuins in aging and diseases.

@article{Guarente2013IntroductionSI,
  title={Introduction: sirtuins in aging and diseases.},
  author={Leonard P. Guarente},
  journal={Methods in molecular biology},
  year={2013},
  volume={1077},
  pages={3-10}
}
Over the past 15 years, the number of papers published on sirtuins has exploded. The initial link between sirtuins and aging comes from studies in yeast, in which it was shown that the life span of yeast mother cells (replicative aging) was proportional to the SIR2 gene dosage. Subsequent studies have shown that SIR2 homologs also slow aging in C. elegans, Drosophila, and mice. An important insight into the function of sirtuins came from the finding that yeast Sir2p and mammalian SIRT1 are NAD… CONTINUE READING