Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials

  title={Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials},
  author={Marvin Martens and Tim Verbruggen and Penny Nymark and Roland C Grafstr{\"o}m and Lyle D. Burgoon and Hristo T. Aladjov and Fernando Torres And{\'o}n and Chris T. A. Evelo and Egon Willighagen},
  journal={Frontiers in Genetics},
A paradigm shift is taking place in risk assessment to replace animal models, reduce the number of economic resources, and refine the methodologies to test the growing number of chemicals and nanomaterials. Therefore, approaches such as transcriptomics, proteomics, and metabolomics have become valuable tools in toxicological research, and are finding their way into regulatory toxicity. One promising framework to bridge the gap between the molecular-level measurements and risk assessment is the… 

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