Introducing Feature Articles in PNAS

  title={Introducing Feature Articles in PNAS},
  author={Randy Schekman},
  journal={Proceedings of the National Academy of Sciences},
  pages={6495 - 6495}
  • R. Schekman
  • Published 17 April 2007
  • Medicine
  • Proceedings of the National Academy of Sciences
I n December 1995, PNAS opened its doors to all authors, and sponsorship by an Academy member was no longer necessary to submit an article to the journal. Since that time, the Direct Submission track has grown to account for approximately 84% of all articles submitted and 50% of all research articles published each year. In this issue of PNAS, we are launching a new category of Direct Submissions. The Feature Article series highlights research articles at the forefront of science, truly… 
3 Citations

Reviewing Science in an Information-Overloaded World

How does a’ scientific fact’ become recognized as a ‘fact’? How does science ‘construct knowledge’ and how does language play a part in this? The answers are not simple because, as Gross (1990, pp.

Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief

  • N. Zagorski
  • Education
    Proceedings of the National Academy of Sciences
  • 2008
The editor-in-chief of PNAS, Randy Schekman, takes a “reductionist” slant to science—identifying, separating, and purifying the individual components of a system so that each can be intently studied until its nuances are understood.



How sterols regulate protein sorting and traffic

  • R. Schekman
  • Biology
    Proceedings of the National Academy of Sciences
  • 2007
Students of cell biology and physiology are in for a treat with the discoveries that cholesterol and an enigmatic but potent derivative, 25-OH cholesterol, exert their effect on gene expression by changing the conformation of two membrane protein sensors that guide a transcription factor precursor into the machinery responsible for vesicular traffic from the endoplasmic reticulum (ER).

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

It is shown that anti-MELADL blocks COPII binding in vitro, and microinjection of Fab anti-L blocks Scap·SREBP movement in cells, and it is speculated that sterols and Insig block SREBP transport by altering the location of MELadL with respect to the membrane, rendering it inaccessible to COPII proteins.

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig

These studies define Insigs as oxysterol-binding proteins, explaining the long-known ability of oxysterols to inhibit cholesterol synthesis in animal cells.