Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis.

@article{Piper1996IntroducingCA,
  title={Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis.},
  author={R D Piper and Deborah J Cook and Roger C. Bone and William J Bill Sibbald},
  journal={Critical care medicine},
  year={1996},
  volume={24 12},
  pages={2059-70}
}
OBJECTIVES To discuss theoretical and practical aspects relating to the design of animal studies investigating the efficacy of novel therapeutic agents for the treatment of sepsis, and to make explicit the process whereby these studies can be evaluated for the purpose of designing clinical trials in humans. DATA SOURCES Relevant articles from the pertinent literature were reviewed. STUDY SELECTION Studies relevant to an evidence-based assessment of clinical studies on therapeutic efficacy… CONTINUE READING

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