• DOI:10.1038/nrm1589
Corpus ID: 18068406

Intrinsically unstructured proteins and their functions

@article{Dyson2005IntrinsicallyUP,
  title={Intrinsically unstructured proteins and their functions},
  author={H. Dyson and P. Wright},
  journal={Nature Reviews Molecular Cell Biology},
  year={2005},
  volume={6},
  pages={197-208}
}

H. Dyson, P. Wright

Published 2005

Biology, Medicine

Nature Reviews Molecular Cell Biology

Many gene sequences in eukaryotic genomes encode entire proteins or large segments of proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly conserved between species in both composition and sequence and, contrary to the traditional view that protein function equates with a stable three-dimensional structure, disordered regions are often functional, in ways that we are only beginning to discover. Many disordered segments fold on binding to their biological… CONTINUE READING

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