Intrinsically unstructured proteins and their functions
@article{Dyson2005IntrinsicallyUP, title={Intrinsically unstructured proteins and their functions}, author={H. Dyson and P. Wright}, journal={Nature Reviews Molecular Cell Biology}, year={2005}, volume={6}, pages={197-208} }
Many gene sequences in eukaryotic genomes encode entire proteins or large segments of proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly conserved between species in both composition and sequence and, contrary to the traditional view that protein function equates with a stable three-dimensional structure, disordered regions are often functional, in ways that we are only beginning to discover. Many disordered segments fold on binding to their biological… CONTINUE READING
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