Intrinsically unstructured proteins and their functions
@article{Dyson2005IntrinsicallyUP,
title={Intrinsically unstructured proteins and their functions},
author={H. Jane Dyson and Peter E. Wright},
journal={Nature Reviews Molecular Cell Biology},
year={2005},
volume={6},
pages={197-208}
}Many gene sequences in eukaryotic genomes encode entire proteins or large segments of proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly conserved between species in both composition and sequence and, contrary to the traditional view that protein function equates with a stable three-dimensional structure, disordered regions are often functional, in ways that we are only beginning to discover. Many disordered segments fold on binding to their biological…
3,311 Citations
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