Intrinsically unstructured proteins and their functions

H Jane Dyson, Peter E. Wright
Published 2005 in Nature Reviews Molecular Cell Biology

Abstract

Many gene sequences in eukaryotic genomes encode entire proteins or large segments of proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly conserved between species in both composition and sequence and, contrary to the traditional view that protein function equates with a stable three-dimensional structure… (More)

DOI: 10.1038/nrm1589

Protein Toxins in Modeling Biochemistry

Raj Kumar, Bal Ram Singh
SpringerBriefs in Biochemistry and Molecular…
2016

Intrinsically unstructured proteins and their functions

Abstract

5 Figures and Tables

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References

a database of protein disorder

Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation.

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins.

Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment.

NMR mapping of the HIV-1 Tat interaction surface of the KIX domain of the human coactivator CBP.

Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein.

Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

Reduced amino acid alphabet is sufficient to accurately recognize intrinsically disordered protein.

Regulation of the p300 HAT domain via a novel activation

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Intrinsically unstructured proteins and their functions

Abstract

5 Figures and Tables

Cited By

Experimental and molecular dynamics studies showed that CBP KIX mutation affects the stability of CBP: c-Myb complex

Model of formin-associated actin filament elongation.

Modulation of Alzheimer’s amyloid b peptide self-assembly – Insights into molecular mechanisms of peptide aggregation associated with Alzheimer’s disease

Bioinformatic Analysis Reveals Conservation of Intrinsic Disorder in the Linker Sequences of Prokaryotic Dual-family Immunophilin Chaperones

A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes

Unified understanding of folding and binding mechanisms of globular and intrinsically disordered proteins

Protein Toxins in Modeling Biochemistry

Ambra1 at a glance.

Deletion of a C-terminal intrinsically disordered region of WRINKLED1 affects its stability and enhances oil accumulation in Arabidopsis.

Fairy “tails”: flexibility and function of intrinsically disordered extensions in the photosynthetic world

References

a database of protein disorder

Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation.

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins.

Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment.

NMR mapping of the HIV-1 Tat interaction surface of the KIX domain of the human coactivator CBP.

Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein.

Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

Reduced amino acid alphabet is sufficient to accurately recognize intrinsically disordered protein.

Regulation of the p300 HAT domain via a novel activation

Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.

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