Intrinsically different retinal progenitor cells produce specific types of progeny

@article{Cepko2014IntrinsicallyDR,
  title={Intrinsically different retinal progenitor cells produce specific types of progeny},
  author={Constance L. Cepko},
  journal={Nature Reviews Neuroscience},
  year={2014},
  volume={15},
  pages={615-627}
}
  • C. Cepko
  • Published 1 September 2014
  • Biology
  • Nature Reviews Neuroscience
Lineage studies conducted in the retina more than 25 years ago demonstrated the multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by individual RPCs, even from a single time point in development, were found to be highly variable. This raised the question of whether this variability was due to intrinsic differences among RPCs or to extrinsic and/or stochastic effects on equivalent RPCs or their progeny. Newer lineage studies that have made use of molecular… 

Evidence for a retinal progenitor cell in the postnatal and adult mouse.

Temporal Progression of Retinal Progenitor Cell Identity: Implications in Cell Replacement Therapies

The mechanisms regulating temporal identity in RPCs are reviewed and how they could be exploited to improve cone photoreceptor production for cell replacement therapies are discussed.

Neurogenesis and Specification of Retinal Ganglion Cells

The different models of retinal neurogenesis proposed over the last decades are reviewed as well as the extrinsic and intrinsic factors controlling it and the cascade of transcription factors that regulate, more specifically, RGC fate are described.

Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins

Two novel knock-in mouse alleles, Atoh7zsGreenCreERT2 and Pou4f2FlagtdTomato, which enabled us to label retinal cells in the two phases of RGC development by fluorescent proteins, can serve as very useful tools for studying the molecular and genetic mechanisms underlying RGC formation.

Photoreceptor Fate Determination in the Vertebrate Retina

Understanding of the molecular mechanisms that regulate photoreceptor fate determination during development is discussed andGene regulatory networks, in which transcription factors interact via cis-regulatory DNA elements, have been discovered that operate within distinct RPCs, and/or newly postmitotic cells, to direct the choice of photore receptor fate.

Otx2 and Oc1 directly regulate the transcriptional program of cone photoreceptor development

It is shown that Otx2 and Oc1 directly regulate the activity of multiple CRMs genome-wide, including near genes important for cone development, such as Rxrg and Neurod1.

Transcriptional logic of cell fate specification and axon guidance in early born retinal neurons revealed by single-cell mRNA profiling

This study profiled 5348 single retinal cells and provided a comprehensive transcriptomic atlas showing the broad diversity of the developing retina at the time when the four early-born cells are being produced.

Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons

Single-cell transcriptomics of early-born retinal neurons unveil cell cycle dynamics, differentiation waves for photoreceptors and R GCs, spatial position and new candidate genes for circuit formation with special emphasis on ipsilaterally projecting RGCs.

Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

The development of single-cell RNA-Sequencing has allowed high resolution analysis of cell type diversity and transcriptional networks controlling cell fate specification, and an unexpected role for ATOH7 expression in regulation of photoreceptor specification during late retinogenesis is identified.

Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types

This study used single-cell RNA-seq to study how newly-born mouse retinal ganglion cell (RGC) precursors diversify into ~45 discrete types, providing a framework for investigating the molecular diversification of discrete types within a neuronal class.
...

References

SHOWING 1-10 OF 157 REFERENCES

Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates

Clonal lineage analysis was used to investigate the progeny of a subset of RPCs, those that express the basic helix–loop–helix transcription factor, Olig2, and indicated that the multipotent progenitor pool is made up of distinctive types of RPC, which have biases toward producing subsets of retinal neurons in a terminal division, with the types of neurons produced varying over time.

Defining retinal progenitor cell competence in Xenopus laevis by clonal analysis

The precision of the order between the clones supports a model in which RPCs proceed through stepwise changes in competence to make each cell type, and do so unidirectionally.

Retinal progenitor cells can produce restricted subsets of horizontal cells

It is suggested that a multipotent progenitor cell produces a mitotic cell fated to make a terminal division that produces two HCs of only one subtype, which suggests a previously undescribed mechanism of cell fate determination in at least a subset of retinal cells that involves decisions made by mitotic cells that are inherited in a symmetric manner by both neuronal daughter cells.

Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions

The results support the notion that stochasticity has a major role during retinal development and therefore possibly in other parts of the central nervous system.

Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina

It is shown that Ascl1 expression defines a competence-restricted progenitor lineage in the retina, providing a new mechanism to explain fate diversification.

Late Retinal Progenitor Cells Show Intrinsic Limitations in the Production of Cell Types and the Kinetics of Opsin Synthesis

Although surrounded by 20-fold more embryonic cells, the postnatal cells did not choose to adopt any fates normally produced only by embryonic cells and appeared to be caused at least in part by a secreted factor released by the embryonic cells that requires the LIFRβ/gp130 complex for signaling.

Individual Retinal Progenitor Cells Display Extensive Heterogeneity of Gene Expression

Comprehensive gene expression profiling is used to define differences among individual progenitor cells of the vertebrate retina, and individual RPCs were found to express multiple bHLH transcription factors, suggesting alternative models to those previously developed concerning how these factors may be coordinated.
...