Intrinsically different retinal progenitor cells produce specific types of progeny

@article{Cepko2014IntrinsicallyDR,
  title={Intrinsically different retinal progenitor cells produce specific types of progeny},
  author={Constance L. Cepko},
  journal={Nature Reviews Neuroscience},
  year={2014},
  volume={15},
  pages={615-627}
}
Lineage studies conducted in the retina more than 25 years ago demonstrated the multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by individual RPCs, even from a single time point in development, were found to be highly variable. This raised the question of whether this variability was due to intrinsic differences among RPCs or to extrinsic and/or stochastic effects on equivalent RPCs or their progeny. Newer lineage studies that have made use of molecular… CONTINUE READING
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