Intrinsically determined cell death of developing cortical interneurons

@inproceedings{Southwell2012IntrinsicallyDC,
  title={Intrinsically determined cell death of developing cortical interneurons},
  author={Derek G. Southwell and Mercedes Francisca Paredes and Rui P. Galvao and Daniel Lamar Jones and Robert C Froemke and Joy Y Sebe and Clara Alfaro-Cervell{\'o} and Yunshuo Tang and Jose Manuel Garc{\'i}a-Verdugo and John L R Rubenstein and Scott C Baraban and Arturo Alvarez-Buylla},
  booktitle={Nature},
  year={2012}
}
Cortical inhibitory circuits are formed by γ-aminobutyric acid (GABA)-secreting interneurons, a cell population that originates far from the cerebral cortex in the embryonic ventral forebrain. Given their distant developmental origins, it is intriguing how the number of cortical interneurons is ultimately determined. One possibility, suggested by the neurotrophic hypothesis, is that cortical interneurons are overproduced, and then after their migration into cortex the excess interneurons are… CONTINUE READING
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