Intrinsically Disordered Proteins in the Neurodegenerative Processes: Formation of Tau Protein Paired Helical Filaments and Their Analysis

@article{krabana2006IntrinsicallyDP,
  title={Intrinsically Disordered Proteins in the Neurodegenerative Processes: Formation of Tau Protein Paired Helical Filaments and Their Analysis},
  author={Rostislav {\vS}krabana and Jozef {\vS}ev{\vc}{\'i}k and Michal Nov{\'a}k},
  journal={Cellular and Molecular Neurobiology},
  year={2006},
  volume={26},
  pages={1083-1095}
}
1. Several intrinsically disordered proteins (IDPs) play principal role in the neurodegenerative processes of various types. Among them, α-synuclein is involved in Parkinson's disease, prion protein in transmissible spongiform encephalopathies, and tau protein in Alzheimer's disease (AD) and related tauopathies. Neuronal damage in AD is accompanied by the presence of tau protein fibrils composed of paired helical filaments (PHF). 2. Tau protein represents a typical IDP. IDPs do not exhibit any… CONTINUE READING