Intrinsically Disordered Energy Landscapes

@inproceedings{Chebaro2015IntrinsicallyDE,
  title={Intrinsically Disordered Energy Landscapes},
  author={Yassmine C Chebaro and Andrew J. Ballard and Debayan Chakraborty and David J. Wales},
  booktitle={Scientific reports},
  year={2015}
}
Analysis of an intrinsically disordered protein (IDP) reveals an underlying multifunnel structure for the energy landscape. We suggest that such 'intrinsically disordered' landscapes, with a number of very different competing low-energy structures, are likely to characterise IDPs, and provide a useful way to address their properties. In particular, IDPs are present in many cellular protein interaction networks, and several questions arise regarding how they bind to partners. Are conformations… CONTINUE READING
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